The explanation of scientific means does not need to go deeper than the scientific ends requires.
Lol. That is funny.
Your OP is about the meaningless of sentience found in materialist/dualist thinking.
No, it's not.
Goodness, you have a lot of accounting to do. Even the origin of meaning is on the list.All we need to do to refute that is explain the origin of sentience, and thus the origin of meaning. We don't need get into the anatomy of sentience except as far as to show it coupled to matter in all cases.
It adds a more accurate understanding of our actual mental functioning and relation to the external world so greater happiness can be achieved through healing issues. It goes where prayer cannot.
You have not shown it cannot be uncoupled, just more shoddy assumptions on your part.
If you don't even know what it is, then surely you are foolish to make many assumptions.